Tablet Presentation

Each Film Coated Tablet Contains:
Etodolac IP             300 mg
Paracetamol IP     325 mg

Etodolac and paracetamol combination reduces pain intensity far more better than its individual use

Indications & Usage

• Rheumatoid arthritis
• Osteoarthritis
• Fever
• Acute Pain
• Juvenile rheumatoid arthritis
• Symptomatic relief of cold

About composition

Etodolac is fall under the category of Non-steroidal anti-inflammatory drugs. As it is used to reduce inflammation, pain, swelling. It has several properties like anti-inflammatory, analgesic, antipyretic. paracetamol is known as acitominophen which is a pain reliever and fever reducer.

Mechanism of action

Both the drugs works by blocking the cox-1and cox-2 enzymes which is involve in the production of prostaglandins which mediates inflammation, fever ,As this enzyme converts arachidonic acid to prostaglandins therefore, it inhibits it.

Pharmacokinetics

Absorption: Both the drugs is absorbed orally by the GIT
Protein binding: It is about 99.9% bound to serum albumin whereas paracetamol do not show protein binding
Metabolism: It is metabolized in the liver and undergoes hydroxylation and glucuronide conjugation.
Excretion: It is excreted in unchanged via the urine.

Side effects

• Nausea
• Diarrhea
• Vomiting
• Itching
• Stomachache
• Dark urine
• jaundice

Contraindications

• Contraindicated in patients with known hypersensitivity and allergy.
• Contraindicated during the third trimester of pregnancy.
• Contraindicated in patients with renal impairment.

Storage conditions

Store it at room temperature